Journal article
Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group
LKM Han, R Dinga, T Hahn, CRK Ching, LT Eyler, L Aftanas, M Aghajani, A Aleman, BT Baune, K Berger, I Brak, GB Filho, A Carballedo, CG Connolly, B Couvy-Duchesne, KR Cullen, U Dannlowski, CG Davey, D Dima, FLS Duran Show all
Molecular Psychiatry | SPRINGERNATURE | Published : 2021
Abstract
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD..
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Grants
Awarded by Fresenius Medical Care North America
Funding Acknowledgements
ENIGMA MDD: This work was supported by NIH grants U54 EB020403 and R01MH116147. BiDirect-Munster: The study was supported by a grant from the German Federal Ministry of Education and Research (BMBF; grant FKZ-01ER0816 and FKZ-01ER1506). Calgary: This study was supported by the Alberta Children's Hospital Foundation. liNG (Heidelberg): This work was partially supported by the Deutsche Forschungsgemeinschaft (DFG) via grants to OG (GR1950/5-1 and GR1950/10-1). CODE: The CODE cohort was collected from studies funded by Lundbeck and the German Research Foundation (WA 1539/4-1, SCHN 1205/3-1, SCHR443/11-1). DIP-Groningen: This study was supported by the Gratama Foundation, the Netherlands (2012/35 to NAG) Dublin: The study was funded by Science Foundation Ireland, with a Stokes Professorship Grant to TF. Edinburgh: The research leading to these results was supported by IMAGEMEND, which received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 602450. This paper reflects only the author's views and the European Union is not liable for any use that may be made of the information contained therein. This work was also supported by a Wellcome Trust Strategic Award 104036/Z/14/Z. FOR2107-Marburg: This work was funded by the German Research Foundation (DFG, grant FOR2107 KR 3822/7-2 to AK; FOR2107 KI 588/14-2 to TK and FOR2107 JA 1890/7-2 to AJ). Leiden: EPISCA was supported by GGZ Rivierduinen and the LUMC. Melbourne: This study was funded by National Health and Medical Research Council of Australia (NHMRC) Project Grants 1064643 (Principal Investigator BJH) and 1024570 (Principal Investigator CGD). Minnesota: The study was funded by the National Institute of Mental Health (K23MH090421), the National Alliance for Research on Schizophrenia and Depression, the University of Minnesota Graduate School, the Minnesota Medical Foundation, and the Biotechnology Research Center (P41 RR008079 to the Center for Magnetic Resonance Research), University of Minnesota, and the Deborah E. Powell Center for Women's Health Seed Grant, University of Minnesota. This work was carried out in part using computing resources at the University of Minnesota Supercomputing Institute. Munster: This work was funded by the German Research Foundation (DFG, grant FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFB-TRR58, Projects C09 and Z02 to UD) and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant Dan3/012/17 to UD). Novosibirsk: This work was supported by Russian Science Foundation (RSF grant 16-15-00128) to LA. SHIP: The Study of Health in Pomerania (SHIP) is part of the Community Medicine Research net (CMR) (http://www.medizin.uni-greifswald.de/icm) of the University Medicine Greifswald, which is supported by the German Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and SHIP-TREND have been supported by a joint grant from Siemens Healthineers, Erlangen, Germany and the Federal State of Mecklenburg-West Pomerania. This study was further supported by the EU-JPND Funding for BRIDGET (FKZ:01ED1615). Stanford: This work was supported by NIH grant R37 MH101495. Sydney: This study was supported by the following National Health and Medical Research Council funding sources: Programme Grant (no. 566529), Centres of Clinical Research Excellence Grant (no. 264611), Australia Fellowship (no. 511921), and Clinical Research Fellowship (no. 402864). The QTIM dataset was supported by the Australian National Health and Medical Research Council (Project Grants No. 496682 and 1009064) and US National Institute of Child Health and Human Development (RO1HD050735). GBF was supported by the funding agencies FAPESP and CNPq, Brazil. CRKC was supported by NIH grants U54 EB020403, RF1 AG041915, RF1AG051710, P41EB015922, R01MH116147, and R56AG058854. JHC was funded by a UKRI Innovation Fellowship. BC-D was supported by a NHMRC CJ Martin Fellowship (APP1161356). CHYF was supported in part by MRC grant, NIHR BRC grant. BRG was supported by the Medical Research Council. LKMH was supported by the Endeavour Leadership Award by the Australian Government Department of Education, Skills and Employment (DESE). TCH was supported by the National Institute of Health (K01MH117442). NJ was supported by NIH grants R01 MH117601, R01 AG059874, U54 EB020403, RF1 AG041915, RF1AG051710, P41EB015922, R01MH116147, and R56AG058854. AFM was supported by the Dutch Organization of Scientific Research under a Vernieuwingsimpuls 'VIDI' Fellowship (grant number 016.156.415) SEM was supported by an Australian National Health and Medical Research Council Senior Research Fellowship (APP1103623). MJP was funded by Ministerio de Ciencia e Innovacion of Spanish Government (ISCIII) through a "Miguel Servet II" (CP16/00020). PGS reports funding by the German Research Foundation (DFG, SA 1358/2-1) and the Max Planck Institute of Psychiatry, Munich. LS was supported by a NHMRC Career Development Fellowship (1140764). JCS was supported by the Pat Rutherford Chair in Psychiatry, UTHealth. PMT was supported in part by NIH grants U54 EB020403, RF1 AG041915, RF1AG051710, P41EB015922, R01MH116147, and R56AG058854. SIT was supported in part by NIH grants U54 EB020403, RF1 AG041915, RF1AG051710, P41EB015922, R01MH116147, and R56AG058854. TTY was supported in part for this study by NCCIH R61AT009864, the National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI Grant Number UL1TR001872, the American Foundation for Suicide Prevention (AFSP), NIMH R01MH085734, NCCIH R21AT009173, UCSF Research Evaluation and Allocation Committee (REAC) and J. Jacobson Fund, and the Brain and Behavior Research Foundation (formerly NARSAD). Amsterdam DIADE: The DIADE study was funded by ZonMW OOG 2007, the Netherlands (#100002034). Cardiff: The Cardiff dataset was supported through a 2010 NARSAD Young Investigator Award (ref: 17319) to XC. CIAM Cape Town: This work was supported by the University Research Council of the University of Cape Town and the National Research Foundation of South Africa. FIDMAG Barcelona: This work was supported by the Generalitat de Catalunya (2014 SGR 1573) and Instituto de Salud Carlos III (CPII16/00018) and (PI14/01151 and PI14/01148). Galway: This work was supported by the Health Research Board, Ireland and the Irish Research Council. Grenoble: This work was supported by research grants from Grenoble University Hospital. Halifax: This work was supported by the Canadian Institutes of Health Research (142255). MOODINFLAME Groningen: This study was funded by EU-FP7-HEALTH-222963 "MOODINFLAME" and EU-FP7-PEOPLE- 286334 "PSYCHAID." Oslo: Funded by the South-Eastern Norway Regional Health Authority (2014097) and a research grant from Mrs. Throne-Holst. Paris: This work was supported by the FRM (Fondation pour la recherche Biomedicale) "Bio-informatique pour la biologie" 2014 grant. Singapore: Funded by Singapore Bioimaging Consortium Research Grant (SBIC RP C-009/2006) and NHG grant (SIG/15012). UNSW: Australian NHMRC Program Grant 1037196 and Project Grants 1063960 and 1066177; and the Janette Mary O'Neil Research Fellowship to JMF. VA San Diego Healthcare/University of California San Diego: This study was supported by R01MH083968, Desert-Pacific Mental Illness Research Education and Clinical Center, and the US National Science Foundation (Science Gateways Community Institutes; XSEDE). Sweden: Funding for the Swedish St. Goran collection was provided by by grants from the Swedish Research Council (2018-02653), the Swedish foundation for Strategic Research (KF10-0039), the Swedish Brain foundation, and the Swedish Federal Government under the LUA/ALF agreement (ALF 20170019, ALFGBG-716801). OAA was funded by the Research Council of Norway (223273, 248778, 273291), NIH (ENIGMA grants). CMB thanks the PERIS grant contract by Departament de Salut CERCA Programme/Generalitat de Catalunya SLT002/16/00331. JMG thanks the support of CIBERSAM and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2017 SGR 1365) and the project SLT006/17/00357, from PERIS 2016-2020 (Departament de Salut). CERCA Programme/Generalitat de Catalunya. TH was supported by the Canadian Institutes of Health Research (103703, 106469), German Research Foundation (DFG grants HA7070/2-2, HA7070/3, HA7070/4), Nova Scotia Health Research Foundation, Dalhousie Clinical Research Scholarship, Brain & Behavior Research Foundation (formerly NARSAD) 2007 Young Investigator and 2015 Independent Investigator Awards. ML was funded by the Swedish state under the ALF-agreement (ALF 20170019, ALFGBG-716801) and the Swedish Research Council (201802653). JR thanks the Miguel Servet contract by the Spanish Ministerio de Ciencia, Innovacion y Universidades. JS was supported by the National Institute of General Medical Sciences (P20GM121312) and the National Institute of Mental Health (R21MH113871). MHS was supported by the funding agencies CAPES, Brazil. DJS was supported by the SAMRC. GMT's work was supported by the National Institutes of Health, Grant T35 AG026757/AG/NIA and the University of California San Diego, Stein Institute for Research on Aging. EV thanks the support of the Spanish Ministry of Science, Innovation and Universities (PI15/00283) integrated into the Plan Nacional de I+D+I y cofinanciado por el ISCIII-Subdireccion General de Evaluacion y el Fondo Europeo de Desarrollo Regional (FEDER); CIBERSAM; and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group (2017 SGR 1365) and the project SLT006/17/00357, from PERIS 2016-2020 (Departament de Salut). CERCA Programme/Generalitat de Catalunya. MVZ was supported by FAPESP, Brazil (grant no. 2013/03905-4). Tim Hahn: was supported by the German Research Foundation (DFG grants HA7070/2-2, HA7070/3, HA7070/4). RK was supported by the National Institute of General Medical Sciences (P20GM121312). CRKC was supported by NIA T32AG058507; NIH/NIMH 5T32MH073526; NIH grant U54EB020403 from the Big Data to Knowledge (BD2K) Program.